The basic Silverpop Engage work flow for creating a new list follows. If your CRM system integrates with Engage then you will never have to worry about this. I would highly recommend using Internet Explorer with the Engage web application. You will also need to enable pop ups because most of the dialogue options come from pop ups. Engage is a very JavaScript/Ajax intensive app and if you have errors, try using IE and enabling less security for the JavaScript to work.